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Investigations with Wisconsin Fast Plants can make the subject matter come alive…or dead, depending on the experimental treatment. This became apparent when a university-based teacher educator and a fifth-grade teacher collaborated on a professional development experience aimed at increasing understanding of how science inquiry could be used effectively in diverse classrooms. This professional development experience centered on creating a unit for fifth-grade students as a part of a study of plant and animal cycles. While the unit included numerous activities, this article focuses on the inquiry portion of the study, as students investigated how pollutants might affect plants.