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There are a number of important practical aspects to setting up and managing a biology classroom. These include strategies for organizing students into groups, conducting laboratory work, maintaining live organisms in the classroom, leading field trips, and using educational technology effectively. Often it is the teachers with years of experience who have found ways to work smarter, not harder. This chapter represents the collective wisdom of several veteran science teachers, organized in an interview format. In the interview you will find suggested answers for several key questions regarding biology course management. The chapter begins with a brief introduction to the teachers (all names are fictional).