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Every science classroom visited has always had a safety rules poster clearly displayed. As a new teacher, I assumed these were issued to every science teacher upon graduation. Hands-on science requires safe practices—a message that was resonated loud and clear in the methods course. This chapter focuses on how safety in a science classroom is more than a poster of rules, and how it can make the difference between an amazing classroom experience and tragedy. It highlights local and national resources available to help develop a successful lab safety program along with steps to take to improve you lab safety.